Automatic Small-Molecule Synthesis Platform

Automatic Small-Molecule Synthesis Platform

The platform comprises two interconnected automated stations for synthesis and post-processing. Within the glove box, the synthesis station utilizes a robotic arm to perform cap opening, weighing, solid feeding from stock hoppers, negative-pressure dosing, liquid dispensing, capping, and magnetic stirring with heating. Once the reaction is complete, the vessels are transferred to the post-processing station for a sequence of automatic operations: cap opening, magnetic stir bar retrieval, nitrogen blow-down with heating, sonication, centrifugation, supernatant decanting, and oven drying. Optional steps, such as washing and recrystallization, are also available. All process data are captured and fully logged by the control software.

Features

In-Glove-Box Automated Formulation

Solid hopper feeding, gravimetric weighing, negative-pressure transfer, liquid dispensing, and automatic capping are all performed within the enclosed glove box environment.

Automated Magnetic Stirring & Heating

Vessels are robotically transported to the stirring-heating station and moved to the output queue upon reaction completion.

Integrated Automatic Post-Processing

A continuous workflow includes stir bar removal, nitrogen blow-down, heating, reagent addition, sonication, centrifugation, supernatant decanting, and oven drying.

Configurable Purification Branches

Optional washing and recrystallization workflows are available to meet diverse product purification requirements.

Specification

Module	Item	Parameters
Glove Box	Layout	SIngle station design
Glove Box	H₂O & O₂ Concentration	＜1 ppm
Solid Dosing Module	Solid Hopper Positions	15
	NegativePressure Dosing	4 rawvial tray positions, compatible with 20 mL vials
	Scale	220 g capacity, readability 0.1 mg (Mettler). Equipped with static eliminator and vibrationdamping
Liquid Dosing Module	Raw Material Bottles	4 types，500mL
Liquid Dosing Module	Pipette Unit	1 set, compatible with 200 μL / 1000 μL pipette tips
Capping & decapping Module	Compatible Vessels	500 mL reagent bottles, 20 mL vials, 50 mL centrifuge tubes
Magnetic Stirring & Heating Module	Reaction Stations	2 sets, each with 12 heated stirring positions, electric heating
	Temperature	RT-150℃
	Stirring Speed	100-1000rpm
Liquid Dispensing Module	Solvent Configuration	4 types of solvents; 6channel dispensing with visual monitoring
Stir Bar Retrieval Module	Function	Automatically pick up stir bar
Heating & Nitrogen Purge Module	Station Layout	12 positions. External gas supply for nitrogen purge system, 12 channels, XZaxis motion supported.
Heating & Nitrogen Purge Module	Heating Unit	Electric heating, ambient to 200 ℃
Shaking & Heating Module	Quantity of Shakers	2
	Frequency	Up to 650 rpm
	Amplitude	10 mm
	Temperature Control System	Oilbath heating. Equipped with 2 programmable temperature circulators, temperature range −20- 100 ℃
Centrifugation Module	Rotor Specification	50mL×6
Centrifugation Module	Maximum Rotation Speed	11,000 rpm
Ultrasonic Module	Ultrasonic Equipment	1 ultrasonic cleaner
Ultrasonic Module	Power	＞100 W
Hardware Configuration	Hardware Configuration	Integrated flash lamp, movable module, 6 monitoring positions
Hardware Configuration	Function	Communicates with software for image recognition and judgment
Robotic Arm	Type	6axis Robotic Arm
	Max Payload	5 kg
	Radius	900 mm
	End Gripper	Quickchange pneumatic gripper with automatic positioning, including pneumatic assembly

Tel：+31 640767826

Europe:

yanghong@osskj.com

Other Regions:

oushisheng@osskj.com

Address：

Databankweg 26, 3821 AL Amersfoort